Researchers at the National Institutes of Health (NIH) and their collaborators have identified a protein, known as RNF114, ...

DNA methyltransferase 1 (DNMT1) is an important DNA methyltransferase that maintains DNA methylation. The retention of DNMT1 ...

Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...

Ubiquitin and the Biology of the Cell, as the editors note, is published 10 years after the first book on ubiquitin appeared and 23 years after the first biochemical description of this ubiquitous ...

NIH-Led Studies Point to Potential Development of a Cataract Drug – Findings Suggests a Surgery-Free Treatment ...

Nurix Therapeutics leverages the ubiquitin-proteasome system for targeted protein degradation (TPD) and elevation (TPE) in cancer and autoimmune diseases, with promising early-stage clinical data. Key ...

"CRLs tag defective, toxic, or superfluous proteins with a small protein called ubiquitin, and mutations or malfunctions impairing CRLs are often associated with diseases, like developmental disorders ...

A research team from Hiroshima University has developed an analysis pipeline to identify unexploited genes for a given ...

Scientists at Livzon Pharmaceutical Group Inc., Shanghai Institute of Organic Chemistry and the University of Michigan have identified proteolysis targeting chimeras (PROTACs) comprising an E3 ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

The growing challenge in cancer therapy lies in overcoming tumor heterogeneity, drug resistance, and associated side effects.

Analysts provide deeper insights through their assessments of 12-month price targets, revealing an average target of $60.5, a high estimate of $87.00, and a low estimate of $48.00. A negative shift in ...