eLife23d
Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation
USP8, a ubiquitin-specific protease, plays a prominent role in the endosomal sorting of a wide range of transmembrane receptors and is a promising target in cancer therapy. Here, we identified that ...
The EMBO Journal27d
The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature
The C2-WW-HECT domain ubiquitin ligase Nedd4L regulates membrane sorting during ... The Nedd4L C2 domain recognized a specific degree of membrane curvature that was generated by the FCHO2 BAR domain, ...
ahajournals.org1mon
Abstract Or109: Regulation of UFM1 modification from ER dynamics to cardiac homeostasis
Ubiquitin (Ub) like protein post-translational modifications ... To determine the role of UFM1 modification in cardiomyocytes we have generated cardiac-specific UFM1-knockout (UFM1CKO) mice. The ...
eLife1mon
ORMDL3 restrains type-I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
Immunoprecipitation coupled with mass spectrometry (IP-MS) assays uncovered that ORMDL3 binds to USP10 (Ubiquitin-Specific Protease 10), which forms a complex with and stabilizes RIG-I through ...
Frontiers1mon
Exploring potential targets for natural product therapy of DN: the role of SUMOylation
Small ubiquitin-related modifiers (SUMOs ... and is indicative of both systemic and renal-specific pathological conditions, efficacious therapeutic strategies are markedly lacking. The role of ...